Download and read online Review of Organic Functional Groups in PDF and EPUB Designed to be used as a self-paced review, this text outlines the functional groups common to organic chemistry, reviewing the general topics of nomenclature, physical and chemical properties, and metabolism. The text provides background material for the formal pharmacy courses in medicinal chemistry, easing the transition from general organic chemistry courses required of all pre-pharmacy students. The Fourth Edition will include a workbook on CD-ROM as well as an index on general drug metabolism. Students who use this text are able to complete difficult tasks such as: drawing a chemical structure or official chemical name; predicting solubility of chemicals in liquids; predicting and showing, with chemical structures, the metabolism of organic functional groups; predicting and showing instabilities, with chemical structures.
Download and read online Review of Organic Functional Groups in PDF and EPUB With its Student Workbook CD-ROM and new case studies, the Fifth Edition of this acclaimed self-paced review enables students to master the principles and applications of organic functional groups. Moreover, it prepares students for the required pharmacy courses in medicinal chemistry by thoroughly covering nomenclature, physical properties, chemical properties, and metabolism. As students progress through the text, they will develop such important skills as drawing chemical structures and predicting the solubility, instabilities, and metabolism of each organic functional group.
Download and read online An Introduction to Medicinal Chemistry in PDF and EPUB This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
Download and read online Organic Chemistry Concepts and Applications for Medicinal Chemistry in PDF and EPUB Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams. Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material
Download and read online Basic Concepts in Medicinal Chemistry in PDF and EPUB Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
Download and read online The Organic Chemistry of Drug Design and Drug Action in PDF and EPUB The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
Download and read online The Organic Chemistry of Medicinal Agents in PDF and EPUB The most concise and streamlined textbook available on organic chemistry for the pharmacy student Organic Chemistry for Pharmacy is a textbook written specifically for the students taking the required Organic/Medical Pharmacy course. Using a building-block approach, the book delivers a basic, yet thorough discussion of the mode of action, therapeutic applications, and limitations of various pharmaceutical agents. Organic Chemistry for Pharmacy is especially written for students who have a limited background in chemistry. In order to make the learning/teaching experience as efficient as possible, Organic Chemistry for Pharmacy includes outstanding pedagogical features such as chapter outlines, chapter summaries, boxed “take away points”, quick-reference tables, and problems within each chapter. The focus and presentation of this text is particularly suited for Organic/Medical Pharmacy courses which are weighted heavily towards Organic, rather than Medical Pharmacy.
Download and read online Introduction to Strategies for Organic Synthesis in PDF and EPUB The stepping-stone text for students with a preliminary knowledge of organic chemistry looking to move into organic synthesis research and graduate-level coursework Organic synthesis is an advanced but important field of organic chemistry, however resources for advanced undergraduates and graduate students moving from introductory organic chemistry courses to organic synthesis research are scarce. Introduction to Strategies for Organic Synthesis is designed to fill this void, teaching practical skills for making logical retrosynthetic disconnections, while reviewing basic organic transformations, reactions, and reactivities. Divided into seven parts that include sections on Retrosynthesis and Protective Groups; Overview of Organic Transformations; Synthesis of Monofunctional Target Molecules; Synthesis of Target Molecules with Two Functional Groups; Synthesis of Aromatic Target Molecules; Synthesis of Compounds Containing Rings; and Predicting and Controlling Stereochemistry, the book covers everything students need to successfully perform retrosynthetic analyses of target molecule synthesis. Starting with a review of functional group transformations, reagents, and reaction mechanisms, the book demonstrates how to plan a synthesis, explaining functional group analysis and strategic disconnections. Incorporating a review of the organic reactions covered, it also demonstrates each reaction from a synthetic chemist's point of view, to provide students with a clearer understanding of how retrosynthetic disconnections are made. Including detailed solutions to over 300 problems, worked-through examples and end-of-chapter comprehension problems, Introduction to Strategies for Organic Synthesis serves as a stepping stone for students with an introductory knowledge of organic chemistry looking to progress to more advanced synthetic concepts and methodologies.
Download and read online Comprehensive Organic Functional Group Transformations II in PDF and EPUB Comprehensive Organic Functional Group Transformations II (COFGT-II) will provide the first point of entry to the literature for all scientists interested in chemical transformations. Presenting the vast subject of organic synthesis in terms of the introduction and interconversion of all known functional groups, COFGT-II provides a unique information source documenting all methods of efficiently performing a particular transformation. Organised by the functional group formed, COFGT-II consists of 144 specialist reviews, written by leading scientists who evaluate and summarise the methods available for each functional group transformation. Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. By systematically treating each functional group in turn the work also identifies what is not known, thus pointing the way to new research areas Follows the systematic layout of the successful 1995 COFGT reference work, based on the arrangement and bonding of hetero-atoms around a central carbon atom The work will save researchers valuable time in their research as each chapter is written by experts who have critically read and reviewed the literature and presented the best methods of forming every known functional group
Download and read online Frequently Prescribed Medications Drugs You Need to Know in PDF and EPUB Frequently Prescribed Medications: Drugs You Need to Know, Second Edition is a practical study tool designed to educate and test students about the drugs that are most commonly used in practice, as well as a helpful reference on drug information for health professionals. This comprehensive resource reviews important concepts regarding the use of specific medications and provides clear and succinct information for the drugs that are commonly utilized in clinical practice, ambulatory practice, and hospital practice, including information on prescription, over-the-counter, and natural products. NEW TO THE SECOND EDITION All-new material, including 98 new drugs, fully updated drug information, and expanded information on pregnancy, controlled substances, and mechanism of action New, more accessible, and colorful design to enable memorization and retention Comprehensive but succinct information for each drug covered 30 new and revised in-text study questions per chapter Available Test Bank for instructor use in quizzes, homework study assignments, or Top 200/300 Exams UPDATES New, more accessible & colorful design Key Points updated Highlight real and drug of choice uses More information on severe drug interactions Hospital drugs/monitoring highlighted The information provided for each drug includes: Drug Class Mechanism of Action Common Brand Name(s) Generic Name Dosage Forms Indications Dosing for Each Indication Initial Dose Maintenance Dose Maximum Dose Renal Dosage Adjustment Adverse Reactions Absolute Contraindications Major Drug Interactions Pregnancy Category Key Counseling Points Including helpful end-of chapter review questions, Frequently Prescribed Medications, Second Edition is a user-friendly resource that will aid student comprehension and serve as a valuable reference for future study and practice. This guide provies excellent test preparation for the Top 200/300 Exams, and a handy reference for practicing health professionals. Instructor Resources: TestBank"
Download and read online Chemistry for Pharmacy Students in PDF and EPUB "This book has succeeded in covering the basic chemistry essentials required by the pharmaceutical science student… the undergraduate reader, be they chemist, biologist or pharmacist will find this an interesting and valuable read." –Journal of Chemical Biology, May 2009 Chemistry for Pharmacy Students is a student-friendly introduction to the key areas of chemistry required by all pharmacy and pharmaceutical science students. The book provides a comprehensive overview of the various areas of general, organic and natural products chemistry (in relation to drug molecules). Clearly structured to enhance student understanding, the book is divided into six clear sections. The book opens with an overview of general aspects of chemistry and their importance to modern life, with particular emphasis on medicinal applications. The text then moves on to a discussion of the concepts of atomic structure and bonding and the fundamentals of stereochemistry and their significance to pharmacy- in relation to drug action and toxicity. Various aspects of aliphatic, aromatic and heterocyclic chemistry and their pharmaceutical importance are then covered with final chapters looking at organic reactions and their applications to drug discovery and development and natural products chemistry. accessible introduction to the key areas of chemistry required for all pharmacy degree courses student-friendly and written at a level suitable for non-chemistry students includes learning objectives at the beginning of each chapter focuses on the physical properties and actions of drug molecules
Download and read online Clinical Biochemistry E Book in PDF and EPUB This edition covers all aspects of the subject needed by medical students. It is a volume in the Illustrated Colour Text series, with the subject matter divided into double-page spreads; this makes the information very accessible to the reader. Full use is made of flow charts and other graphics; clinical "boxes;" summary points; case histories; and clinical photographs. The whole orientation of the book is to concentrate on how clinical biochemistry relates to the care of the patient and to ensure that the medical student understands how to interpret laboratory. Covers clinical biochemistry from the point of view of the clinician using the diagnostic service Presents topics in easily accessible two-page spreads Includes mini case histories, key point boxes, flowcharts, and summary points Well illustrated with four-color drawings and clinical photographs New appendix added of annotated web resources for students to take further many of the topics covered in the book. To reflect the difficulties people have sometimes in analyzing hyper- and hypo-kalaemia, the existing spread is split into two - one spread on hyperkalaemia and another on hypokalaemia. The spread on hypertension will be revised and updated to reflect the fact that biochemistry is used as much or more in guiding treatment as it is in screening for secondary hypertension. Spreads on Myocardial Infarction, Cancer and Tumour Markers will all substantially revised and updated.
Download and read online FASTtrack Physical Pharmacy in PDF and EPUB A concise guide providing the physicochemical background to the design and use of pharmaceutical dosage forms.This FASTtrack book is derived from the textbook Physicochemical Principles of Pharmacy and is designed to be used alongside it for those revision periods when time is short. It includes key points, tips, self assessment questions/answers and memory maps to aid with revision.For the new edition there will be an additional chapter on pharmaceutical nanotechnology.
Download and read online Comprehensive Medicinal Chemistry III in PDF and EPUB Comprehensive Medicinal Chemistry III, Third Edition provides a contemporary and forward looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
Download and read online Organic Synthesis in PDF and EPUB Organic Synthesis: Strategy and Control is the long-awaited sequel to Stuart Warren’s bestseller Organic Synthesis: The Disconnection Approach, which looked at the planning behind the synthesis of compounds. This unique book now provides a comprehensive, practical account of the key concepts involved in synthesising compounds and focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. A comprehensive, practical account of the key concepts involved in synthesising compounds Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations Focuses on reactions that really work rather than those with limited application Contains extensive, up-to-date references in each chapter Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.