Genetics of Bone Biology and Skeletal Disease

Filename: genetics-of-bone-biology-and-skeletal-disease.pdf
ISBN: 9780123878298
Release Date: 2013
Number of pages: 621
Author: R. V. Thakker
Publisher: Academic Press

Download and read online Genetics of Bone Biology and Skeletal Disease in PDF and EPUB This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder. Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broad range of genetic bone issues, as opposed to searching through thousands of journal articles. Provides a common language for bone biologists and geneticists to discuss the development of bone cells and genetics and their interactions in the development of disease Researchers in all areas bone biology and genetics will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays For those clinical researchers who are also MDs, correct diagnosis (and therefore correct treatment) of bone diseases depends on a strong understanding of the molecular basis for the disease.


Principles of Bone Biology Two Volume Set

Filename: principles-of-bone-biology-two-volume-set.pdf
ISBN: 9780080539607
Release Date: 2002-01-19
Number of pages: 1696
Author: John P. Bilezikian
Publisher: Academic Press

Download and read online Principles of Bone Biology Two Volume Set in PDF and EPUB Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The most current and timely source of information about the biology and pathology of bone Provides succinct coverage of the subject Contributors include over 200 of the most respected researchers in the field Extensive table of contents and index for easy reference Easy-to-read and highly informative to both the newcomer and the initiated to the field Spans the spectrum from molecular biology to in vivo pharmacology Complete bibliography with each entry fully referenced for additional background reading First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996


Basic and Applied Bone Biology

Filename: basic-and-applied-bone-biology.pdf
ISBN: 9780123914590
Release Date: 2013-06-11
Number of pages: 390
Author: David B. Burr
Publisher: Academic Press

Download and read online Basic and Applied Bone Biology in PDF and EPUB This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. Presents an in-depth overview of skeletal biology from the molecular to the organ level Offers "refresher" level content for clinicians or researchers outside their areas of expertise Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology


Osteoimmunology

Filename: osteoimmunology.pdf
ISBN: 9780128006276
Release Date: 2015-09-23
Number of pages: 376
Author: Joseph Lorenzo
Publisher: Academic Press

Download and read online Osteoimmunology in PDF and EPUB Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology. This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics. Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget’s disease, the genetics of bone disease, and bone cancer metastasis. Explains the intricate interaction between the immune system and bone Features detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systems Facilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems


Bone Pathology

Filename: bone-pathology.pdf
ISBN: 1597453471
Release Date: 2009-12-02
Number of pages: 408
Author: Jasvir S. Khurana
Publisher: Springer Science & Business Media

Download and read online Bone Pathology in PDF and EPUB Bone Pathology is the second edition of the book, A Compendium of Skeletal Pathology that published 10 years ago. Similar to the prior edition, this book complements standard pathology texts and blends new but relatively established information on the molecular biology of the bone. Serving as a bench-side companion to the surgical pathologist, this new edition reflects new advances in our understanding of the molecular biology of bone. New chapters on soft-tissue sarcomas and soft-tissue tumors have been added as well as several additional chapters such as Soft-tissue pathology and Biomechanics. The volume is written by experts who are established in the field of musculoskeletal diseases. Bone Pathology is a combined effort from authors of different specialties including surgeons, pathologists, radiologists and basic scientists all of whom have in common an interest in bone diseases. It will be of great value to surgical pathology residents as well as practicing pathologists, skeletal radiologists, orthopedic surgeons and medical students.


Pediatric Bone

Filename: pediatric-bone.pdf
ISBN: 9780123820402
Release Date: 2012
Number of pages: 853
Author: Francis H. Glorieux
Publisher: Academic Press

Download and read online Pediatric Bone in PDF and EPUB Pediatric Bone is the first book to be published to deal exclusively with the biology and diseases of bone as they affect children. Rapid advances have been made in our understanding of the mechanisms and factors controlling the growth and development of bone, and these are discussed in detail in this book. Further, the various diseases of bone which are peculiar to children are highlighted and discussed in the light of our current knowledge with regard to the causation, clinical signs and treatment. The book is aimed to provide those clinicians interested in children's diseases and basic scientists with a comprehensive resource covering the various aspects of bone health and disease in children Key Features * Deals exclusively with bone development and diseases of children and each chapter written by an * Fully referenced providing an appendix of usually difficult to find information on the investigation of pediatric bone disease and reference values * Covers both the physiology of bone and mineral homeostasis in children and diseases in one book * Includes a CD-ROM of images


Bones and Cartilage

Filename: bones-and-cartilage.pdf
ISBN: 0080454151
Release Date: 2005-06-20
Number of pages: 792
Author: Brian K. Hall
Publisher: Academic Press

Download and read online Bones and Cartilage in PDF and EPUB Bones and Cartilage provides the most in-depth review ever assembled on the topic. It examines the function, development and evolution of bone and cartilage as tissues, organs and skeletal systems. It describes how bone and cartilage is developed in embryos and are maintained in adults, how bone reappears when we break a leg, or even regenerates when a newt grows a new limb, or a lizard a tail. This book also looks at the molecules and cells that make bones and cartilages and how they differ in various parts of the body and across species. It answers such questions as “Is bone always bone? “Do bones that develop indirectly by replacing other tissues, such as marrow, tendons or ligaments, differ from one another? “Is fish bone the same as human bone? “Can sharks even make bone? and many more. * Complete coverage of every aspect of bone and cartilage * Full of interesting and unusual facts * The only book available that integrates development and evolution of the skeleton * Treats all levels from molecular to clinical, embryos to evolution * Written in a lively, accessible style * Extensively illustrated and referenced * Integrates analysis of differentiation, growth and patterning * Covers all the vertebrates as well as invertebrate cartilages * Identifies the stem cells in embryos and adults that can make skeletal tissues


Dynamics of Bone and Cartilage Metabolism

Filename: dynamics-of-bone-and-cartilage-metabolism.pdf
ISBN: 008045626X
Release Date: 2006-07-24
Number of pages: 920
Author: Markus J. Seibel
Publisher: Academic Press

Download and read online Dynamics of Bone and Cartilage Metabolism in PDF and EPUB This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, this latest edition is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. *Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components *Part II covers the organizational structure and cellular metabolism of bone and cartilage *Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease


Identification of Pathological Conditions in Human Skeletal Remains

Filename: identification-of-pathological-conditions-in-human-skeletal-remains.pdf
ISBN: 0080525636
Release Date: 2003-01-10
Number of pages: 645
Author: Donald J. Ortner
Publisher: Academic Press

Download and read online Identification of Pathological Conditions in Human Skeletal Remains in PDF and EPUB Identification of Pathological Conditions in Human Skeletal Remains provides an integrated and comprehensive treatment of pathological conditions that affect the human skeleton. There is much that ancient skeletal remains can reveal to the modern orthopaedist, pathologist, forensic anthropologist, and radiologist about the skeletal manifestations of diseases that are rarely encountered in modern medical practice. Beautifully illustrated with over 1,100 photographs and drawings, this book provides essential text and materials on bone pathology, which will improve the diagnostic ability of those interested in human dry bone pathology. It also provides time depth to our understanding of the effect of disease on past human populations. Key Features *Comprehensive review of skeletal diseases encountered in archeological human remains * More than 1100 photographs and line drawings illustrating skeletal disease including both microscopic and gross features * Based on extensive research on skeletal paleopathology in many countries for over 35 years * Review of important theoretical issues in interpreting evidence of skeletal disease in archeological human populations


Principles of Bone Biology Two Volume Set

Filename: principles-of-bone-biology-two-volume-set.pdf
ISBN: 9780080539607
Release Date: 2002-01-19
Number of pages: 1696
Author: John P. Bilezikian
Publisher: Academic Press

Download and read online Principles of Bone Biology Two Volume Set in PDF and EPUB Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The most current and timely source of information about the biology and pathology of bone Provides succinct coverage of the subject Contributors include over 200 of the most respected researchers in the field Extensive table of contents and index for easy reference Easy-to-read and highly informative to both the newcomer and the initiated to the field Spans the spectrum from molecular biology to in vivo pharmacology Complete bibliography with each entry fully referenced for additional background reading First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996


Connective Tissue and Its Heritable Disorders

Filename: connective-tissue-and-its-heritable-disorders.pdf
ISBN: 9780471461173
Release Date: 2003-04-14
Number of pages: 1201
Author: Peter M. Royce
Publisher: John Wiley & Sons

Download and read online Connective Tissue and Its Heritable Disorders in PDF and EPUB The Second Edition of Connective Tissue and Its Heritable Disorders: Molecular, Genetic, and Medical Aspects is the definitive reference text in its field, with over 40% more pages on the nature, diagnosis, and treatment of disease than its predecessor. Collecting new research on disorders detailed in the first edition as well as on those previously excluded, editors Peter Royce and Beat Steinmann provide the most up-to-date clinical and scientific information for medical specialists treating affected individuals. Features of this revised and updated volume include detailed reviews of the clinical diagnosis, mode of inheritance, risk of recurrence, and prenatal diagnosis of each inherited connective tissue disorder; a thorough description of the morphology of connective tissues; a completely updated and revised section on the biology of the extracellular matrix; and the addition of syndromes such as craniosyntosis, and disorders of sulfate metabolism.


Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Filename: primer-on-the-metabolic-bone-diseases-and-disorders-of-mineral-metabolism.pdf
ISBN: 9781118453919
Release Date: 2013-06-11
Number of pages: 1104
Author:
Publisher: John Wiley & Sons

Download and read online Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism in PDF and EPUB Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease. Visit the companion site to access supplementary materials including videos, editorial team details, downloadable figures, and more.


Endocrinology Adult and Pediatric

Filename: endocrinology-adult-and-pediatric.pdf
ISBN: 9780323321952
Release Date: 2015-02-25
Number of pages: 2700
Author: J. Larry Jameson
Publisher: Elsevier Health Sciences

Download and read online Endocrinology Adult and Pediatric in PDF and EPUB Considered the definitive source in its field for over 35 years, Endocrinology: Adult and Pediatric, has been thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology. Unique perspectives from a team of trusted, world-renowned experts ensure this medical reference book remains the most highly-regarded text in the field. Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information quickly, while still getting the complete coverage you expect. Expanded coverage for key topics such as pediatric endocrinology and obesity mechanisms and treatment, in addition to today's hot topics in endocrinology, including endocrine disruptors, bariatric surgery, androgen deficiency, genetic causes of obesity, endocrine rhythms, and the use of tyrosine kinase inhibitors in thyroid cancer. New content addressing the latest advances in testosterone and estrogen replacement, as well as the new causes of calcium and phosphate disorders, new molecular causes of endocrine cancers, new genetic causes of reproductive disorders, and more. Updated clinical guidelines for diabetes, lipid disorders, obesity management, osteoporosis, and more, as well as essential treatment updates for the medical management of acromegaly, Cushing's Disease, hypercalcemia, and diabetes mellitus. New Key Points provide snapshots of what to expect in each chapter, or serve as a refresher of what you just read. Consult this title on your favorite e-reader.


Biological Anthropology of the Human Skeleton

Filename: biological-anthropology-of-the-human-skeleton.pdf
ISBN: 9781118211656
Release Date: 2011-09-23
Number of pages: 680
Author: M. Anne Katzenberg
Publisher: John Wiley & Sons

Download and read online Biological Anthropology of the Human Skeleton in PDF and EPUB "This book is virtually required reading for biological anthropologists and will be a useful, up-to-date primer on osteological analyses for a wider audience." —The Quarterly Review of Biology, March 2009 "… a comprehensive guide to the ever-changing discipline of physical anthropology… provides an in depth introduction to human skeletal biology. The structure of the book makes it easy for the reader to follow the progression of the field of human skeletal biology." —PaleoAnthropology, 2009 Issue The First Edition of Biological Anthropology of the Human Skeleton is the market-leading reference and textbook on the scientific analysis of human skeletal remains recovered from archaeological sites. Now, featuring scores of new or thoroughly revised content, this Second Edition provides the most comprehensive and up-to-date coverage of the topic available. Like the previous edition, this Second Edition is organized into five parts with contributing chapters written by experts in the field of human skeletal biology: Part One covers theory and application; Part Two discusses morphological analyses of bone, teeth, and age changes; Part Three reviews prehistoric health and disease; Part Four examines chemical and genetic analysis of hard tissues; and Part Five closes with coverage of quantitative methods and population studies. Each chapter includes a review of recent studies, descriptions of analytical techniques and underlying assumptions, theory, methodological advances, and speculation about future research. New or thoroughly revised content includes: Techniques in the analysis of human skeletal and dental remains Extensive coverage of new technologies, including modern morphometric techniques Advances in the field of forensic anthropology Enhanced discussion of ethical terms regarding the study of aboriginal peoples' remains where those people are no longer the dominant culture This book serves as an indispensable research guide to biological anthropologists, osteologists, paleoanthropologists, and archaeologists. Now with a stronger focus on teaching complex material to students, this revised edition provides enhanced case studies and discussions for future directions, making it an invaluable textbook for advanced undergraduates and graduate students in biological anthropology and forensic anthropology programs.


Metabolic Bone Disease and Clinically Related Disorders

Filename: metabolic-bone-disease-and-clinically-related-disorders.pdf
ISBN: 9780080536279
Release Date: 1997-10-08
Number of pages: 811
Author: Louis V. Avioli
Publisher: Academic Press

Download and read online Metabolic Bone Disease and Clinically Related Disorders in PDF and EPUB Metabolic Bone Disease, Third Edition is the new, expanded edition of the classic text, featuring the latest advancements and research information in this fast-moving field. The Third Edition includes the most up-to-date information on molecular mechanisms, basic biology, pathophysiology, and diagnosis and management strategies of metabolic bone disease. Key Features * Edited by "fathers of the field" * An expanded version of a classic AP text * Complete coverage of a fast-growing field